contents
http://pubs.acs.org/ac ISSN 0003-2700
June 1, 2001 / Vol. 73, No. 11
features 312 A
COVER STORY
Microfluidics: Controlling Fluids in Small Places. Most lab-on-a-chip devices are designed to move and direct fluids. Thus, understanding the principles of microfluidics is essential to developing ever more sophisticated miniature analysis systems. Nolan Polson of Thermo Biostar and Mark Hayes of Arizona State University discuss the challenges of microfluidics, list approaches that are being explored, and propose new directions.
Going around the bend. 312 A
320 A
Prefractionation Techniques in Proteome Analysis. Deciphering the human genome was a big job, but proteomic analysis promises to be even more complicated. Not only are there lots of proteins to study, but many are present in only low concentrations. Pier Giorgio Righetti and Annalisa Castagna of the University of Verona (Italy) and Ben Herbert of Proteome Systems (Australia) describe a prefractionation system that helps identify those hard-to-find proteins.
news 301 A
Analytical Currents Biosensing arrays based on RNA. Golden optical sensors. Unsafe air at home. Quantifying chirality. Spin labels for “thrifty” NMR screening. One handy mixing machine! MS for genotyping STRs. No medals for these bacteria.
305 A
Research Profiles ECL for near-field imaging. How electrogenerated chemiluminescence avoids some of the problems of near-field scanning optical microscopy. Multipurpose nanopore sensors. Nature uses them, so why not analytical chemists? Engineering cell-like membrane channels to detect analytes. Putting a fine point on ESI. Creating protein microarrays with electrospray ionization.
308 A
Meeting News Flexible immunoassays on a chip. MS.
Parallel spraying. 307 A
290 A
A N A LY T I C A L C H E M I S T R Y / J U N E 1 , 2 0 0 1
Classifying enzyme inhibitors using
contents
Golden optical sensors. 301 A F
F
F
F
O F
CH2
+ O
F
F PFBHA
NH2
C H
H H
F H
Formaldehyde
C O F
F
H N
C H
Oxime
Unsafe air. 302 A 309 A
Government and Society Microarray standards adopted. Fresenius gets a new identity.
NACLA steps forward.
departments 293 A
Editorial Analytical Chemistry’s Impact. How do you measure the impact of this Journal on the analytical sciences?
295 A
In AC Research
327 A
Product Review DNA Sequencers Rely on CE. The “heroes” of the Human Genome Project can read as many as half a million bases a day.
333 A
AC Educator* Teaching the Essential Principles. Miguel Valcárcel of the University of Córdoba (Spain) argues that learning begins with a sound knowledge of the analytical thought processes and basic principles.
The core of education. 333 A
1C
AC Research Contents
2371–2685
AC Research
2686
Author Index
*Includes supporting information, which is available at http://pubs.acs.org/ac
Proteins, proteins, proteins. 320 A
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291 A
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e d i to ri a l
Analytical Chemistry’s Impact F
irst, I am pleased to announce that Analytical Chemistry is now accepting manuscript submissions electronically (http://pubs.acs.org/ac). This is an exciting step by which we hope to better serve the analytical chemistry community. I want to discuss the impact of research papers published in this Journal. Analytical Chemistry, as a general journal, serves the entire range of analytical measurement sciences, selecting papers for publication on the basis of their significance in advancing the fundamentals and applications of analytical measurements. Research articles published in the Journal have historically had a large impact on the course of the discipline; the impact is, in fact, significantly larger than that of any other analytical sciences journal. The associated prestige attracts authors who wish to see their work published in a journal where readers expect to see the best and “hottest” results. Analytical Chemistry greatly values these authors and the readers of their papers. When reading Analytical Chemistry, I find breathtaking the implications of the research articles for the discipline’s future. How is the impact of Analytical Chemistry measured? One way is to consider the many seminal papers—those that open up a long line of further research such as capillary electrophoresis— which have been published in these pages (for example, see Anal. Chem. 2000, 72, 324 A–329 A). There are also quantitative measures. For example, the 901 articles published in 1999 in Analytical Chemistry have been cited in other subsequent papers a total of 44,870 times, a value dwarfing that of other analytical journals. Personal readership of print articles is classically harder to quantify, but a recent library use study (http://www.library. wisc.edu/libraries/Chemistry/cost.htm) showed the “use rate” of ACS journals, including Analytical Chemistry, to be much higher than that of non-ACS journals. In addition, the use of Analytical Chemistry ’s Web edition is readily tracked, and I can report that the number of “views” and downloads has grown steadily since our launch in 1997. In 2000, downloads of Web pages totaled well over one million, or nearly 3,000/day. Finally, the Institute for Scientific Information’s (ISI’s) 1999 “impact factor” for Analytical Chemistry was a high 4.56. The 1999 impact factor is the number of 1999 literature citations to articles (and editorials and letters) published in 1997 and 1998
divided by the sum of the 1997 and 1998 articles. Impact factor is a useful tool for evaluating a journal’s role in providing the most significant research to the community. For every year since 1980—save three—Analytical Chemistry has had the highest impact factor among analytical journals. Impact factors have some eccentricities that their users should appreciate. First, it is possible that a single, not necessarily outstanding, article can dominate the year’s citation, as was the case when the unfortunate 1989 Journal of Electroanalytical Chemistry paper on “cold fusion” garnered an impact factor of 12.2. Second, review journals and “advances” book series should not be compared with research journals, because authors often cite review articles as an efficient way of referencing a large body of older literature. Review journal impact factors tend to be large; for example, Electroanalytical Chemistry (an advances series) had a 6.75 impact factor in 1999 based on a ratio of 735 citations to 3 published articles. When a review publication such as Electroanalytical Chemistry is compared with research journals, it can assume an apparent leadership role, as was the case in ISI’s analytical journal lists for 1998 and 1999. Last, extremely selective research journals such as Science and Nature, which consistently publish a small number of papers, can attain large impact factors; whereas a journal that publishes an increasing number of papers year after year runs the risk of diluting its highly cited ones with those that are “merely” excellent. Interestingly, while Analytical Chemistry published over 35% more papers in 1999 compared with 1993, its impact factor increased from 4.08 to 4.56 during that period. Because growth in published papers and an increase in impact factor tend to run in opposite directions, the increase in the Journal’s impact factor is significant. Analytical Chemistry has a proud heritage of leadership in the analytical discipline, which is maintained by the mutually reinforcing high standards of its authors and reviewers. These scholars are the most valued and significant aspects of this Journal.
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EDITOR Royce W. Murray University of North Carolina
ASSOCIATE EDITORS Daniel W. Armstrong
Reinhard Niessner
Iowa State University/Ames Laboratory
Technische Universität München (Germany)
Catherine C. Fenselau
Robert A. Osteryoung
University of Maryland
North Carolina State University
William S. Hancock
Edward S. Yeung
ThermoFinnigan
Iowa State University/Ames Laboratory
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